Structurally simplified macrolactone analogues of halichondrin B.

Boris M. Seletsky,Yuan Wang,Lynn D. Hawkins,Monica Palme,Gregory J. Habgood,Lucian Dipietro,Murray J. Towle,Kathleen A. Salvato,Bruce F. Wels,Kimberley K. Aalfs,Yoshito Kishi,Bruce A. Littlefield,Melvin J. Yu

Structurally simplified macrolactone analogues of halichondrin B.

2004

Boris M. Seletsky
Yuan Wang
Lynn D. Hawkins
Monica Palme
Gregory J. Habgood
Lucian Dipietro
Murray J. Towle
Kathleen A. Salvato
Bruce F. Wels
Kimberley K. Aalfs
Yoshito Kishi
Bruce A. Littlefield
Melvin J. Yu

A structurally simplified macrolactone analogue of halichondrin B was identified that retains the potent cell growth inhibitory activity of the natural product in vitro.

Keywords:

Natural product
Combinatorial chemistry
Chemical synthesis
Biological activity
Chemistry
Halichondrin B
Biochemistry
Stereochemistry
Cell growth
In vitro

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