Carbon dots up-regulate heme oxygenase-1 expression towards the acute lung injury therapy

2021 
Pneumonia is a kind of inflammation, which can cause high morbidity and mortality, and the treatment of pneumonia has received widespread attention. Heme oxygenase-1 (HMOX 1) is a cell protective enzyme and can generate the anti-inflammatory response. Here, we demonstrate a degradable carbon dots (from L-ascorbic acid, CDs-1) can up-regulate the expression of HMOX 1 in animal cells and tissues, which have a therapeutic effect on LPS-induced acute lung injury in mice. In in-vitro experiments, CDs-1 were confirmed could significantly up-regulate the expression of mRNA and protein of HMOX 1, which can increase the expression of HMOX 1 by 5 times in a short time, decreasing the reactive oxygen species level in cellular inflammation model induced by LPS. Furthermore, a series of in vivo comparative experiments show that CDs-1 could effectively treat acute lung injury and improve the survival rate of mice to 80%. Our work provides a practical way for the treatment of acute inflammation and the promising application of CDs on anti-inflammatory.
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