Enantioselective total synthesis of both diastereomers of preclavulone-A methyl ester

Abstract The enantioselective total synthesis of preclavulone-A methyl ester and its diastereomer was achieved from enantiomerically pure 5 in a stereocontrolled manner. The absolute stereochemistry of naturally occurring preclavulone-A methyl esters was determined by comparison of the [α] D value.