Contrast Media in CEDM

The basic concept that creates contrast in X-ray images is the different absorption of X-rays by different tissues. For example, dense breast glandular tissue does absorb far more X-rays in comparison to fatty tissue. In many experimental designs, the X-ray absorption of dense breast glandular tissue is similar to that of water. Unfortunately the difference in the X-ray absorption between tissues is very little and hence the similarity between the image contrast of tumorous tissue in comparison to glandular tissue in dense breasts.