Glucocorticoids induce the formation and release of anti-inflammatory and anti-phospholipase proteins into the peritoneal cavity of the rat.
1982
1
Dexamethasone and hydrocortisone induce the release of anti-phospholipase proteins into the peritoneal cavities of rats.
2
Adrenocorticotropic hormone (ACTH) also releases these proteins in normal but not in adrenalectomized rats.
3
Peritoneal lavage proteins were separated by ion-exchange and size exclusion chromatography. The anti-phospholipase activity occurred in four separate fractions with the major component having an apparent mol. wt. of 40 k.
4
Column fractions containing these anti-phospholipase proteins had anti-inflammatory effects in the rat carrageenin pleurisy model whereas other fractions were inactive.
5
The proteins appear to be identical to macrocortin and lipomodulin, the ‘second messengers’ of glucocorticoid hormone action on the arachidonate system.
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