Pindolol potentiate the antidepressant effect of venlafaxine by inhibiting 5-HT1A receptor in DRN neurons of mice.

Introduction: Antidepressants increase the level of 5-HT in the somatodendritic region of the serotonergic dorsal raphe nucleus (DRN) neurons in the first few days of their usage, which, in turn, i...