One-pot Synthesis of 3-Aryl-substituted 1-Hydroxy-2-acylindolizines

A new method for the formation of C‐C bonds in a one-pot synthesis of 1-hydroxy-2-acyl-3arylindolizines (acyl: 2-pyridylformyl, thienylformyl; aryl: phenyl, pyridyl, thienyl) from the reaction of 1,3-diketones with aldehydes has been evaluated. X-Ray diffraction studies of single crystals have provided structural information about the so-formed indolizines. In the crystalline state, the hydroxyl units form intra- or intermolecular hydrogen bonds to the acyl functionalities. The color of these indolizines depends on the pH value of the solvent.