Naphthyl piperazines with dual activity as 5-HT1D antagonists and 5-HT reuptake inhibitors.
2007
Abstract SAR around a known molecule with dual 5-HT 1D antagonist and 5-HT transporter inhibitory activity has led to the discovery of molecules with improved dual activity and reduced cross-reactivity toward other aminergic receptors (5-HT 1B , α 1 , and D 2 ).
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