Spirocyclic Nonpeptide Glycoprotein IIb—IIIa Antagonists. Part 1. Design of Potent and Specific 3,9-Diazaspiro[5.5]undecanes.
2010
Abstract The synthesis and biological activity of novel glycoprotein IIb–IIIa antagonists containing the 3,9-diazaspiro[5.5]undecane nucleus are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spirocyclic structures as a central template for nonpeptide RGD mimics.
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