ent-Abietane lactones from Euphorbia
2017
Extracted from Euphorbia, ent-Abietane lactones can be classified into several categories,
such as Jolkinolides and Helioscopinolides, according to their structural features. The study of ent-
Abietane lactones could date back to 1972, when Jolkinolide A and B were first isolated from
Euphorbia jolkini Boiss. Since then, many other ent-Abietane lactones have been extracted from
different species of Euphorbia. Their bio-activities include anti-tumor activity, anti-inflammatory
activity as well as anti-bacterial activity. Among them, derivatives of Jolkinolide B draw the most
attention for their high anti-tumor activity. There are many studies focus on the syntheses of
Jolkinolides. In 1989, the first and efficient synthesis of Jolkinolides was accomplished by Katsumura
et al. Their strategy to construct the last ring of Jolkinolides contributes a lot to the following studies. In
the following thirty years, there are also other semi-syntheses of Jolkinolides conducted, basing on
different starting materials. In this review, we will give a brief clarification of ent-Abietane lactones, as
well as their bio-activities and syntheses.
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