Application of Automatic System for the Preparation and Delivery of Sterile Solutions in Varicella Vaccine Production

Objective: Application of automatic system for the preparation and delivery of sterile solutions in varicella vaccine production meets the demand of scale production of varicella vaccine by use of cell factory. And it reduces differences between batches. Methods: The solutions for varicella vaccine passage are prepared by automatic system or manual operation mode. It is compared in cell growth, operating time, and product test of the two modes. Results: In the case of the same amount of cell recovery, almost no differences between the varicella vaccine production batches can be found, and it takes shorter operation time in use of automatic operation system than the manual operation mode. And the detection of indicators is qualified. Conclusion: The use of automatic system to prepare and deliver sterile solutions in varicella vaccine production can improve the homogeneity between vaccine batches, reduce labor intensity, shorten operation time, reduce transportation and other intermediate links, and decline the risk of contamination, which is able to meet the requirements for varicella vaccine cell factory scale production.