SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL POLYCYCLIC THIENOPYRIDAZINE DERIVATIVES

A series of novel thienopyridazine derivatives has been synthesized using 9-aminodibenzo[f,h]thieno[2,3-c]cinnoline-8-carbonitrile as starting material. The target products exhibit promising antibacterial and antifungal properties against bacterial strains E. coli, S. aureus, B. subtilis, and K. pneumoniae and fungal strains A. fumigatus and C. albicans. The highest antimicrobial activity against all tested microorganisms demonstrate pyridothienocinnoline derivatives.