Ultra-Sensitive Stripping SWV for Determination of Ertapenem via ZnONPs/MWCNT/CP Sensor: Greenness Assessment

Abstract The present work concerns with operation of a chemically improved carbon paste electrode via incorporation of zinc oxide nanoparticles and multi-walled carbon nanotubes in an ultra-sensitive electrochemical sensor for determination of ertapenem (EP) in authentic material, marketed products and human plasma. The proposed adsorptive stripping square wave voltammetric technique was advantageously found as a nano-sensitive method that facilitated to quantify EP selectively in plasma without metabolite interference. The sensor fabrication was introduced and morphological structure was elucidated by X-ray diffraction, scanning and transmission electron microscopies. The sensor surface was characterized by cyclic voltammetry, electrochemical impedance spectroscopy, chronocoulometry and stripping voltammetry. EP has showed a linear dependence over the ranges; 0.4–4.0 and 0.4–3.2 μM for two peaks and detection limits of 85.0 and 78.0 nM were achieved. Practically, ZnONPs/MWCNT/CP electrode can efficiently act as a multi-purpose analytical sensor. Cmax of EP and sensor efficacy favorably encouraged clinical application in plasma. Meanwhile, it is capable to determine EP in vials and in presence of different degradates for QC laboratories application. The results declare the excellent performance of the utilized sensor presented by detection limits at nano-levels, ultra-high sensitivity, diverse applications and green chemistry analysis achievements.