Protein expression of CyclinD1 and Ki-67 in HepG2 cells proliferation inhibiting induced by methyl jasmonate

Objective: Study the protein expression of cyclinD1 and Ki-67 in HepG2 cells proliferation inhibiting induced by methyl jasmonate(MeJA).Methods: Detect protein expression of cyclinD1 and Ki-67 in HepG2 cells by immunocytochemistry.Results: with the effect of MeJA on HepG2 cells for 48h: the protein expression of cyclinD1 and Ki-67 has significantly declined(P0.01).Conclusions: MeJA declines the protein expression of cyclinD1 and Ki-67,change the expression of cell cycle-related protein,causing cells of proliferation cycle decline,which play a role against liver cancer.