Ancestral genetic composition in a population of South Western Colombian using autosomal AIM-INDELS

Abstract The Colombian population, for his history contains an ancestral mix of Europeans, Native Americans and Africans, these mixing ratios can be determined by Ancestry-Informative Markers (AIMs), this markers allow us to observe stratification in genetic association studies. The aim of this study was to determine the mixing ratios in a population sample of 500 individuals the Department of Cauca, Colombia with three different origins (European, Native American and African) using a set of 46 AIMs insertion-deletion (AIM-INDELs). The software STRUCTURE v 2.3.4 was used to determine the ancestral mixture. The average composition of the population of the Department of Cauca was 48% for Native American, 39% for European and 14% for African. It showed that the ancestral composition of the Department of Cauca has a greater contribution of Native Americans and Europeans compared to Africans which could be explained by the European migrations during the conquest of America.