Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population
2019
Single nucleotide polymorphisms (SNPs) in immune related gene may influence the susceptibility of cancer. We selected
inducible T cell costimulator (
ICOS
) rs4404254 T>C, rs10932029 T>C,
CD28
rs3116496 T>C and CD80 rs7628626 C>A SNPs and assessed the potential relationship of these SNPs with hepatocellular carcinoma (HCC) risk. A total of 584 HCC cases and 923 healthy controls were recruited. And SNPscan TM genotyping assay was used to obtain the genotypes of
ICOS
,
CD28
and CD80 polymorphisms. We found that
ICOS rs10932029 T>C polymorphism significantly increased the risk of HCC (additive model: adjusted OR, 1.59; 95% CI, 1.13-2.22;
P = 0.007; homozygote model: adjusted OR, 1.12; 95% CI, 0.31-4.03;
P = 0.867; dominant model: adjusted OR, 1.58; 95% CI, 1.14-2.19;
P = 0.007 and recessive model: adjusted OR, 1.02; 95% CI, 0.28-3.68;
P = 0.974). However,
ICOS rs4404254 T>C, CD28 rs3116496 T>C and CD80 rs7628626 C>A SNPs were not associated with the risk of HCC. To evaluate the effects of
ICOS rs10932029 T>C on HCC risk according to different age, gender, chronic HBV infection, tobacco consumption and drinking status, we carried out a stratification analysis. We found that
ICOS rs10932029 T>C polymorphism might increase the risk of HCC in male, ≥ 53 years, never smoking, never drinking and non-chronic HBV infection subgroups. Our study highlights that
ICOS rs10932029 T>C polymorphism may confer the susceptibility to HCC. It may be beneficial to explore the relationship between variants in immune related genes and the development of HCC.
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