Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening

Nicholas E. Calcaterra,Daniel J. Hoeppner,Huijun Wei,Andrew E. Jaffe,Brady J. Maher,James C. Barrow

Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening

2016

Nicholas E. Calcaterra
Daniel J. Hoeppner
Huijun Wei
Andrew E. Jaffe
Brady J. Maher
James C. Barrow

Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening

Keywords:

hERG
Drug discovery
Intracellular
Pharmacology
High-throughput screening
Bortezomib
HEK 293 cells
Transport protein
Biology
Mutation
Gene expression
Potassium channel
cellular localization
Gene isoform
Cell biology

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