Preparation method of 2-bromo-3'-methoxyacotophenone

The present invention relates to the preparation method of a kind of medicine intermediate, be specifically related to the preparation method of a kind of 2 bromine 3 ' methoxyacetophenones.The preparation method that the present invention uses, with 1-Phenylethanone., dimethyl sulfate and bromating agent as primary raw material, through nitrification, reduction, diazotising, hydrolyzes, methylates and the step such as bromination reaction prepares target product.The advantage of the preparation method that the present invention provides is, each step reaction yield is all more than 80%, and the purity of gained target product 2 bromine 3 ' methoxyacetophenone is up to 99.2%, and it has the advantages such as low cost, productivity is high, purity is good.In preparation process, reaction condition is gentle, and simple to operate, the harm to environment is little, and this preparation method is applicable to large-scale production.