Relationship between ERCC2 single nucleotide polymorphisms and male idiopathic infertility in Ningxia

Objective: To explore the influence of the DNA repair gene ERCC2 single nucleotide polymorphisms( SNPs) rs13181,rs1618536,and rs1799793 on male idiopathic infertility in Ningxia,China. Methods: Using MassArray,we conducted a case-control study and genotyped three ERCC2 SNPs rs13181,rs1618536,and rs1799793 for 351 males( aged 31. 0 ± 4. 2 years) with idiopathic infertility and another 327 normal fertile men( aged 33. 0 ± 5. 9 years) as controls. Results: The ERCC2 AnyG-anyA-anyA genotypes were significantly associated with an increased risk of idiopathic infertility( OR 0. 414,95% CI 0. 176- 0. 970),while the three single ERCC2 SNPs rs13181,rs1618536,and rs1799793 showed no significant differences between the cases and controls( P 0. 05). Conclusion: The ERCC2 SNPs rs13181,rs1618536,and rs1799793 play a role of interaction in male idiopathic infertility in Ningxia,contributing to the risk of the disease.