Flexible Organic Framework-Based Anthracycline Prodrugs for Enhanced Tumor Growth Inhibition

Zi-Yue Xu,Hong-Kun Liu,Yan Wu,Yun-Chang Zhang,Wei Zhou,Hui Wang,Dan-Wei Zhang,Da Ma,Zhan-Ting Li

Flexible Organic Framework-Based Anthracycline Prodrugs for Enhanced Tumor Growth Inhibition

2021

Zi-Yue Xu
Hong-Kun Liu
Yan Wu
Yun-Chang Zhang
Wei Zhou
Hui Wang
Dan-Wei Zhang
Da Ma
Zhan-Ting Li

A water-soluble flexible organic framework FOF-hz of low cytotoxicity has been synthesized from a pyridinium-derived tetracationic tetraaldehyde and a citric acid-derived tritopic acylhydrazine (1:...

Keywords:

Combinatorial chemistry
antitumor activity
Hydrazone
Chemistry
Acylhydrazine
Cytotoxicity
Dynamic covalent chemistry
tumor growth inhibition
Anthracycline
Prodrug

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