Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5)

Peter Bach,Karolina Nilsson,Tor Svensson,Udo Bauer,Lance G. Hammerland,Alecia Peterson,Andreas Wållberg,Krister Österlund,David Karis,Maria Boije,David Wensbo

Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5)

2006

Peter Bach
Karolina Nilsson
Tor Svensson
Udo Bauer
Lance G. Hammerland
Alecia Peterson
Andreas Wållberg
Krister Österlund
David Karis
Maria Boije
David Wensbo

Studies of structure–activity relationships for the linker in a new series of metabotropic glutamate receptor 5 antagonists are presented together with in vitro and in vivo pharmacokinetic data.

Keywords:

Metabotropic glutamate receptor 2
Linker
APICA
Metabotropic receptor
Biochemistry
Metabotropic glutamate receptor 5
Stereochemistry
Organic chemistry
Structure–activity relationship
Metabotropic glutamate receptor
Chemistry
Metabotropic glutamate receptor 1
In vivo
Glutamate receptor

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations