Enantiospecific hydrolysis of esters of nonsteroidal antiinflammatory drugs using lipase of Candida cylindracea

Abstract Enantiospecific hydrolysis of esters of 2-arylpropionic acids with antiinflammatory activity has been carried out. The racemic acids were synthetized by Willgerodt—Kindler synthesis in good yields. The enzymatic hydrolysis of the esters was carried out in a batch reactor with 0.2 M substrate concentration.