human antibodies adhering to mesothelin, and uses thereof

An isolated monoclonal antibody, or a part of antigen binding thereof, wherein the antibody is a human antibody which binds to human mesothelin and comprises: (a) a variable region CDR1 heavy chain comprising SEQ ID NO: 2 ; (B) a variable heavy chain region CDR2 comprising SEQ ID NO: 5; (C) a variable region CDR3 heavy chain comprising SEQ ID NO: 8; (D) a variable light chain region CDR1 comprising SEQ ID NO: 11; (E) a light chain variable region CDR2 comprising SEQ ID NO: 14; and (f) a light chain variable CDR3 region comprising SEQ ID NO: 17, or (a ') a variable heavy chain region CDR1 comprising SEQ ID NO: 3; (B ') a variable heavy chain region CDR2 comprising SEQ ID NO: 6; (C ') a variable region CDR3 heavy chain comprising SEQ ID NO: 9; (D ') a variable light chain region CDR1 comprising SEQ ID NO: 12; (E ') a variable light chain region CDR2 comprising SEQ ID NO: 15; and (f) a variable light chain CDR3 region comprising SEQ ID NO: 18.