3′ UTRs in the Eye of the TIGER

Many human genes generate mRNAs with alternative 3′ untranslated regions (3′ UTRs), which can modulate protein function. In a recent Cell paper, Ma and Mayr (2018) unveil a major membraneless organelle, termed the TIS granule-endoplasmic reticulum (TIGER), which enables specific 3′ UTRs to encipher protein localization.