Amino-Supported Solid Palladium Catalyst for Chemo- and Stereoselective Domino Reactions.

An amino-supported solid palladium-catalyzed oxidative domino reaction has been developed for the diastereoselective construction of alkyne-substituted cyclopentenol compounds. This hetero-ge-neous catalyst exhibits high efficiency and excellent chemoselectivity, as well as good recyclability. The chemoselectivity of the domino reactions was readily controlled by switching the solvent and catalyst. Chiral syntheses and an oxidative carbocyclization-borylation reaction have also been developed based on the heterogeneous Pd-catalyzed domino strategy.