Development of radiolabeled radachlorin complex as a possible tumor targeting agent

Developing radiolabeled tetrahydropyrrole complexes for ultimate dual-purpose imaging as well as dual-therapeutic modalities was of our interests. [67Ga] labeled radachlorin was prepared followed by stability tests, partition coefficient determination as well as biodistribution studies in wild type rodents using scarification and SPECT imaging. However, the results showed high and prolonged uptake of the labeled compound in many organs that the potential of the labeled compound for diagnostic proposal is weak.