A New Approach to the Synthesis of 2-Aminoimidazo[1,2-a]pyridineDerivatives Through Rapid Parallel Synthesis

Different substituted 6-(2,6-difluorobenzoyl)-imidazopyridines 3 have been prepared using rapid parallel synthesis. Key cyanamide intermediate 4 was prepared from chloropyridine 1, and alkylated at the endocyclic nitrogenwith different bromoacetophenones (prepared also in rapid parallel synthesis fashion). Subsequent cyclization was performed in situ with EtOAC/H 2 O to give target molecules.