Rh(III)-Catalyzed Csp2-Csp3 σ-Bond Enolation of α-Indolyl Alcohols.

Xinwei Hu,Zheng Tan,Li Xiong,Can Yang,Huanfeng Jiang,Wei Zeng

Rh(III)-Catalyzed Csp2-Csp3 σ-Bond Enolation of α-Indolyl Alcohols.

2021

Xinwei Hu
Zheng Tan
Li Xiong
Can Yang
Huanfeng Jiang
Wei Zeng

A Rh(III)-catalyzed Csp2-Csp3 σ-bond carbenoid functionalization of α-(2-indolyl)alcohols with acceptor/acceptor diazo compounds has been developed. This transformation provides an efficient strategy to assemble stable C2-enolated indole skeletons via Csp2-Csp3 σ-bond cleavage.

Keywords:

Diazo
Medicinal chemistry
Carbenoid
Surface modification
Chemistry
Transformation (genetics)
Cleavage (embryo)
Catalysis
Indole test
Acceptor

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