Cyclobutane derivatives as potent NK1 selective antagonists
2006
Abstract A series of novel cyclobutane derivatives as potent and selective NK 1 receptor antagonists is described. Several compounds in this series exhibited high in vitro binding affinity ( K i ⩽ 1 nM), and potent inhibition of central NK 1 receptor following oral administration. Syntheses of these compounds are also described herein.
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