Effect of thyrocytes from transgenic mice expressing thyroid specific MHC class II on autologous T lymphocyte in vitro

Thyrocytes expressing MHC class Ⅱ molecules were separated from transgenic mice and were co-cultured with autologous spleen T lymphocytes. T cells did not proliferate and were not activated, but CD4+ T cells were promoted into apoptosis. Key words: Thyrocytes;  Major histocompatibility class Ⅱ ; T-lymphocytes