Daño Celular Hepático por CC14 - Importancia de las Interacciones de Metabolitos Reactivos de CC14 con Componentes Celulares y de la Peroxidación de Lípidos en el Proceso

The relative importance of the deleterious processes lipid peroxidation (LP) and covalent binding (CB) elicited by carbon tetrachloride CCl4 was studied. Strong antioxidants like vitamin E, prometazine and N,N'-diphenyl-p-phenylendiamine, shown to inhibit LP but not CB, and pyrazole and cystamine, known to inhibit CB but not LP, were administered to rats and their effects on the CCl4 liver toxicity were evaluated. In vivo results were not in accord with in vitro observations made on isolated hepatocytes. Although most authors agree that the alterations observed in the early stage, during 6 hours after CCl4 intoxication, are due to both process they do not coincide about the relative importance of CB and LP. However, present studies attribute significance to each one of them, suffice it to say that when either CB or LP occurs the global process ends in cellular death and further necrosis.