Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome

Soham Gupta,Päivi Ylä-Anttila,Simone Callegari,Ming Han Tsai,Henri Jacques Delecluse,Maria G. Masucci

Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome

2018

Soham Gupta
Päivi Ylä-Anttila
Simone Callegari
Ming Han Tsai
Henri Jacques Delecluse
Maria G. Masucci

The N-terminal domains of the herpesvirus large tegument proteins encode a conserved cysteine protease with ubiquitin- and NEDD8-specific deconjugase activity. The proteins are expressed during the ...

Keywords:

ENCODE
Virology
Molecular biology
Cysteine protease
Ubiquitin
Biology
Epstein–Barr virus
Viral tegument
TRIM25
RIG-I
Immunoprecipitation
Cloning

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