Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases

1Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101318, China, 2Graduate University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, China, 3Laboratory of Molecular Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital/Institute, Beijing 100142, China and 4Beijing Protein Innovation, Beijing 101318, China