Ecofriendly synthesis, antimicrobial and antispermatogenic activity of triorganotin(IV) complexes with 4′‐nitrobenzanilide semicarbazone and 4′‐nitrobezanilide thiosemicarbazone

New series of triorganotin(IV) complexes with 4′-nitrobenzanilide semicarbazone (L1H) and 4′-nitrobenzanilide thiosemicarbazone (L2H) of the type [R3Sn(L)] (R = -CH3, -C6H5 and n-C4H9) were synthesized under microwave irradiation. All the complexes were characterized by elemental analysis, conductance measurements, molecular weight determinations and spectral data, viz., IR, UV–vis, 1H, 13C and 119Sn NMR. The central tin atoms of these complexes are all five-coordinated with trigonal bipyramidal geometry. In order to assess their growth inhibitory potency semicarbazone, thiosemicarbazone and their triorganotin(IV) complexes were tested in vitro against some pathogenic fungi and bacteria. Also the ligands and their organotin(IV) complexes were studied to assess the effects of long-term ingestion of these compounds on fertility, body and reproductive organ weights. The biochemical analyses were also performed on blood samples and reproductive organs of male rats. The findings have been presented in this paper. Copyright © 2009 John Wiley & Sons, Ltd.