Positive Acid Balance in Patients Undergoing Chronic Hemofiltration

In Hemodialysis, while the kind and rate of Metabolizable Organic Anion (MOA) delivery are well characterized phenomena, the same cannot be said for the kind and rate of MOA dissipation. In fact the usually considered and chemically measured Lactate, BOHB and AcAc are only fractions of all the titratable MOA (1). The aim of the present investigation was to clarify: a) whether the dialysis buffer balance, carried out by measuring all the titratable MOA, still remains positive as when only BOHB and Lactate are considered; b) whether a dialysis net gain of buffer can be found, adequate to offset the interdialytic accumulation of metabolic H ions.