Synthesis of 2[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-yl)propyl]-4-[4-tetrafluoropropoxy)phenyl]-3-(2H,4H)-1,2,4-triazol-3-thione—A Novel and Potent Azole Antifungal Agent

Jitendra Sattigeri,Sachin Sethi,Mohammad Salman

Synthesis of 2[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-yl)propyl]-4-[4-tetrafluoropropoxy)phenyl]-3-(2H,4H)-1,2,4-triazol-3-thione—A Novel and Potent Azole Antifungal Agent

2010

Jitendra Sattigeri
Sachin Sethi
Mohammad Salman

A simple approach involving refluxing appropriately disubstituted thiosemicarbazide 8 in presence of formic acid for the synthesis of 1, a potent azole antifungal agent, has been described.

Keywords:

Organic chemistry
Azole antifungal
Chemistry
Formic acid

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