Asymmetric Synthesis of trans‐β‐Lactams by a Kinugasa Reaction on Water
2013
The asymmetric Kinugasa reaction was performed on pure water for the first time without the need for any organic co-solvents. In contrast to most asymmetric Kinugasa reactions, trans-β-lactams were obtained as the major products in good yields, enantioselectivities, and diastereoselectivities (up to 90 % yield, 98 % ee, and >99:1 d.r.). This reaction is atom-economical, environmentally friendly, and affords synthetically useful but challenging products.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
125
References
44
Citations
NaN
KQI