Highly Selective Synthesis of α-Aminoamide Utilizing an Umpolung Reaction and Characteristics of α-Hydrazonoester.
2021
An umpolung reaction with α-hydrazonoesters was investigated, and it was found that α-N,N-dialkylaminoamides could be directly synthesized in yields up to 92% via a concomitant rearrangement of dialkylamino groups. As an application, a short synthesis of an inhibitor of glycine type-1-transporter was accomplished via subsequent functional group transformations in 28% overall yield.
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
43
References
0
Citations
NaN
KQI