Effect of dextran and modified dextrans on the uptake and degradation of β-galactosidase in isolated liver cells

Abstract 1. 1. Conjugation of β-galactosidase with either dextran, methylated dextran or acetylated dextran had only a small effect on uptake of the enzyme in isolated rat parenchymal and nonparenchymal liver cells. 2. 2. Conjugation of β-galactosidase with dextran or the modified dextrans, reduced the intracellular degradation of the enzyme by up to about 45%. 3. 3. Methylated dextran had less effect than unmodified dextran or acetylated dextran on reducing the intracellular degradation of β-galactosidase.