Sonogashira Coupling Catalyzed by the Cu(Xantphos)I—Pd(OAc)2 System.

Abstract An efficient Pd(OAc) 2 /Cu(Xantphos)I system for Sonogashira coupling is disclosed. Aryl bromides/iodides and electron-poor aryl chlorides were suitable for this reaction. The experimental results suggest that Cu(Xantphos)I plays a unique role in which the phosphine ligand coordinates with copper.