Effects of polysaccharides from Potentilla anserine on the levels of cytokines in tumor mice.

[Objective] To study the effects of polysaccharides from Potentilla anserine (PAP) on the levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) from peripheral blood. [Method] The mice models with tumor S180 were established and treated with 50, 100 and 200 mg/kg PAP by gastric perfusion, respectively. The inhibition rate of S180 tumor was measured to investigate the antitumor activity in vivo of PAP. The levels of IL-2 and TNF-α in mice peripheral blood were determined with ELISA. [Result] The tumor inhibition rates were 46.41%, 52.29% and 59.48% in different groups treated with 50,100 and 200 mg/kg PAP in vivo, respectively. Of these, the inhibition rate of CY and low-dose PAP was equal to that of medium- and high-dose PAP, significantly higher than that of cyclophosphamide. Three dose groups of PAP could significantly increase the content of IL-2 and TNF-α spleen index. [Conclusion] The compound PAP could improve the antitumor activity and immunological function of S180 tumor-bearing mice.