In Vitro Antibacterial Studies of Ciprofloxacin-imines and Their Complexes with Cu(II),Ni(II),Co(II), and Zn(II)

Some new transition metal complexes of ciprofloxacin-imines derived from ciprofloxacin and p-substituted anilines were synthesized and characterized on the basis of physical properties, conductance measurements, elemental analysis, UV/Vis., infrared and nuclear magnetic resonance spectroscopy. These ligands as well as their metal complexes were also evaluated for their antibacterial activity against several bacterial strains, such as Staphylococcus aureus, Bacillus subtilus, Salmonella typhae, and E. coli. It was found that metal complexes are more antibacterial as compared to uncomplexed ligands. The present study was carried out in search of a target antibiotic instead of a broad spectrum one.