Curcumin and Genistein: the Combined Effects on Disease-associated CFTR Mutants and their Clinical Implications
2013
Genistein and curcumin are major components of Asian foods, soybean and curry turmeric respectively. These compounds
have been intensively investigated for their chemical and biological features conferring their anti-cancer activity. Genistein and curcumin
have also been investigated for their potentiation effects on disease-associated CFTR mutants such as ΔF508 and G551D.
Recently, we investigated the combined effect of genistein and curcumin on G551D-CFTR, which exhibits gating defects without abnormalities
in protein synthesis or trafficking using the patch-clamp technique. We found that genistein and curcumin showed additive
effects on their potentiation of G551D-CFTR in high concentration range and also, more importantly, showed a significant synergistic effect
in their minimum concentration ranges. These results are consistent with the idea that multiple mechanisms are involved in the action
of these CFTR potentiators.
In this review, we revisit the pharmacology of genistein and curcumin on CFTR and also propose new pharmaceutical implications of
combined use of these compounds in the development of drugs for CF pharmacotherapy.
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