PEG BONDED FLUORESCENT-HYDROGEL FIBERS WITH LESS INFLAMMATION FOR LONG-TERM SUBCUTANEOUS GLUCOSE MONITORING

We present polyethylene glycol (PEG) bonded poly-acrylamide (PAM) hydrogel fibers with glucose-responsive monomer to monitor blood glucose concentration in vivo for over 4 months. To realize long-term subcutaneous glucose monitoring, we employed fiber-structure and PEG-bonded PAM hydrogel. The fiber-shaped sensors can be injected to subcutaneous tissues, remain in an implantation site and be easily removed after use. PEG can enhance biocompatibility, resulting in maintaining the functionality of implanted sensors in vivo for a long-period. The implanted PEG-bonded PAM fibers showed less inflammation, glowed through the skin and continuously responded to blood glucose concentration, thereby promising practical, long-term subcutaneous glucose monitoring.