1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists.

Jeremy M. Travins,Ronald C. Bernotas,David H. Kaufman,Elaine Quinet,Ponnal Nambi,Irene Feingold,Christine Huselton,Anna Wilhelmsson,Annika Goos-Nilsson,Jay E. Wrobel

1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists.

2010

Jeremy M. Travins
Ronald C. Bernotas
David H. Kaufman
Elaine Quinet
Ponnal Nambi
Irene Feingold
Christine Huselton
Anna Wilhelmsson
Annika Goos-Nilsson
Jay E. Wrobel

Abstract A series of 1-(3-aryloxyaryl)benzimidazoles incorporating a sulfone substituent ( 6 ) was prepared. High affinity LXR ligands were identified (LXRβ binding IC 50 values

Keywords:

ATP-binding cassette transporter
Benzimidazole
Agonist
Nuclear receptor
Biochemistry
Liver X receptor
Signal transduction
Organic chemistry
Sulfone
Chemistry
Substituent
Chemical synthesis
Stereochemistry
Structure–activity relationship
Ligand

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations