Merging Kinetic Resolution with C-H Activation: An Efficient Approach for Enantioselective Synthesis
2021
In last two decades tremendous progress has been made in transition-metal (TM)-catalyzed C−H bond functionalization, paving the way to design complex molecules. Despite significant advances, enantioselective C-H activation is still in the age of infancy. For the enantioselective synthesis, several TM catalysts based approaches are well known, including kinetic resolution (KR) and its advanced versions [dynamic kinetic resolution (DKR) and parallel kinetic resolution (PKR)]. These strategies have recently been successfully applied synergetically with the TM catalyzed C-H activation to achieve enantioselective synthesis in a more economical and sustainable way. This review will summarize the recent advances made towards merging KR with TM catalyzed C-H activation for enantioselective synthesis.
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