Monoclonal Antibodies Recognizing Inter-Alpha-Trypsin-Inhibitor and its Related Fragments - Evidence for the Involvement of the Proteinase Inhibitor in Cutaneous (Patho-)Physiology

Proteolytic enzymes and their regulatory counterparts - the proteinase inhibitors - are likely to play an important role in the physiology and pathophysiology of human epidermis and dermis1. Numerous proteinases have been identified in the human skin 1,2,3 and have subsequently been characterized by chemical and immunological methods.