Diastereoselective Michael reactions of (1R)-(+)-camphor methyl ketone enolates with nitro olefins
2001
Abstract The reaction of the sodium enolate of the methyl ketone 2 with a range of nitro olefins proceeds readily to give the corresponding Michael adducts in good yields and diastereoselectivities. Subsequent oxidative cleavage of the acyloin moiety provides γ-nitroalkanoic acids along with (1 R )-(+)-camphor, the chiral auxiliary of the process, which can be recovered and reused.
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