Malignant Mixed Tumor of Salivary Gland in a Dog

A tumor was observed in the left mandible of a 3-year-old male Shih-Tzu dog. Histopathology revealed neoplastic alveolar proliferation of round cells, sarcomatoid proliferation of round to spindle-shaped cells and an existing parotid gland tissue around the tumor. A cancellous bone framework was also seen throughout the tumor. The tumor cells in the sarcomatoid area were positive and weakly positive for vimentin and cytokeratin, respectively, demonstrating their myoepithelial character. We diagnosed this tumor as a malignant mixed tumor of the salivary glands, because of the location of the tumor, its invasiveness into the surrounding tissue and the identification of both epithelial and myoepithelial tumor cells.