Chromosomal Analysis of Sperm
2017
Several checkpoint mechanisms that regulate the different stages of male meiosis can eliminate defective germ cells and ensure spermatozoa with a normal chromosome content. For this reason, spermatogenesis can be partially arrested in any of the maturation stages, resulting in oligozoospermia (reduced
sperm number), or it can be completely arrested, resulting in azoospermia (absence of sperm). However,
if these control mechanisms are deficient, any of the abnormal cell lines can evade the checkpoints and
give rise to chromosomally abnormal spermatozoa.
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